Literature summary for 2.7.1.1 extracted from

Hussain, S.; Richardson, E.; Ma, Y.; Holton, C.; De Backer, I.; Buckley, N.; Dhillo, W.; Bewick, G.; Zhang, S.; Carling, D.; Bloom, S.; Gardiner, J.
Glucokinase activity in the arcuate nucleus regulates glucose intake (2015), J. Clin. Invest., 125, 337-349.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P17712	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
hypothalamus	-	Rattus norvegicus	-

General Information

General Information	Comment	Organism
physiological function	in fasted rats, glucokinase activity is specifically increased in the arcuate nucleus but not other regions of the hypothalamus. Pharmacologic and genetic activation of glucokinase in the arcuate nucleus of rodent models increases glucose ingestion, while decreased arcuate nucleus glucokinase activity reduces glucose intake. ATP-sensitive potassium channel and P/Q calcium channel activity are required for glucokinase-mediated glucose intake. Altered glucokinase activity affects release of the orexigenic neurotransmitter neuropeptide Y in response to glucose	Rattus norvegicus

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Release 2023.1 (January 2023)